Subacute Toxicity of Crocus Sativus L. (Saffron) Stigma Ethanolic Extract in Rats
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چکیده
منابع مشابه
Safety evaluation of saffron stigma (Crocus sativus L.) aqueous extract and crocin in patients with schizophrenia
OBJECTIVES Saffron is the stigma of Crocus sativus L., which has the potentials to play a role in the treatment of many diseases. Although many researches are now going on this precious spice, there are few data on saffron safety in human, especially in patients with chronic mental illnesses. This study aimed to evaluate the short-term safety and tolerability of both saffron and crocin (its maj...
متن کاملHepatoprotective effect of Crocus sativus (saffron) petals extract against acetaminophen toxicity in male Wistar rats
OBJECTIVES Acetaminophen (APAP) toxicity is known to be common and potentially fatal. This study aims to investigate the protective effects of hydroalcoholic extract, remaining from Crocus sativus petals (CSP) against APAP-induced hepatotoxicity by measuring the blood parameters and studying the histopathology of liver in male rats. MATERIALS AND METHODS Wister rats (24) were randomly assigne...
متن کاملProtective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats
OBJECTIVES Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. MATERIALS AND METHODS Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. ...
متن کاملantioxidant activity of ethanolic extract of crocus sativus l. (saffron) stigma against rifampin induced hepatotoxicity
background: tuberculosis continues to be a common health problem worldwide. rifampin, an antibiotic used routinely for tuberculosis chemotherapy is documented to be a potent hepatotoxicant. the aim of the present study was to assess the antioxidant activity of ethanolic extract of crocus sativus l . stigma (eecsl.s) against rifampin induced hepatotoxicity in the rats. materials and methods: mal...
متن کاملSafety evaluation of saffron stigma (Crocus sativus L.) aqueous extract and crocin in patients with schizophrenia
Objectives: Saffron is the stigma of Crocus sativus L., which has the potentials to play a role in the treatment of many diseases. Although many researches are now going on this precious spice, there are few data on saffron safety in human, especially in patients with chronic mental illnesses. This study aimed to evaluate the short-term safety and tolerability of both saffron and crocin (its ma...
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ژورنال
عنوان ژورنال: American Journal of Pharmacology and Toxicology
سال: 2007
ISSN: 1557-4962
DOI: 10.3844/ajptsp.2007.189.193